Businesses are facing "increasingly unbearable pressures" because of soaring energy and fuel bills, according to Wales' economy minister.
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Vaughan Gething is due to meet with businesses leaders on Wednesday to discuss the issues they are facing.
But he has called on the UK government to use "powers only they have at their disposal to intervene in this crisis".
The two candidates for the prime minister's job have signalled they will offer help if elected on 5 September.
Mr Gething said the cost of living crisis was not just having a "significant impact" on families.
"We're also facing a cost of business crisis, with businesses across Wales facing increasingly unbearable pressures because of soaring energy and fuel bills," he said.
Mr Gething has called on the UK government to adopt "measures to reduce inflation and provide the significant additional help people and businesses need".
"Unless they act now, they risk inflicting significant harm on the Welsh economy. This cannot be allowed to happen."
David Chapman, Welsh executive director of Hospitality UK, told BBC Radio Wales Drive that 13,000 direct Welsh jobs were at risk if there was no help for the hospitality industry from the UK government.
The Welsh government has said it providing support to small-to-medium enterprises with £116m in non-domestic rates help in retail, leisure and hospitality sectors in 2022-23.
