Stocks in Asia sank and bond yields were elevated on Wednesday, as investors braced for another aggressive interest rate hike from the U.S. Federal Reserve later in the day.
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Japan's Nikkei dropped 1.26 per cent and touched a two-week low. Australia's benchmark share index slid 1.35 per cent and South Korea's Kospi fell 0.9 per cent.
Chinese blue chips declined 0.82 per cent, while Hong Kong's Hang Seng lost 1.26 per cent.
MSCI's broadest index of Asia-Pacific shares lost 1 per cent.
That follows a sell-off on Wall Street overnight that knocked 1.13 per cent off the SP 500, although futures pointed to a slightly higher open on Wednesday.
The Fed headlines a week in which more than a dozen central banks announce policy decisions, including the Bank of Japan and Bank of England on Thursday.
Sweden's Riksbank surprised markets overnight with a full percentage-point hike, and warned of more to come over the next six months.
Despite that, bets for Fed tightening stayed stable.
Markets are pricing in an 81 per cent chance of another 75-basis-point increase, and see a 19 per cent probability of a full percentage point rise.
Global yields rose amid expectations of further tightening.